BDBM50269948 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one::CHEMBL514554::D3RKN_2::PF-228::US10266549, Example 32::US10774092, Example 32

SMILES CS(=O)(=O)c1cccc(c1)CNc2c(cnc(n2)Nc3ccc4c(c3)CCC(=O)N4)C(F)(F)F

InChI Key InChIKey=HESLKTSGTIBHJU-UHFFFAOYSA-N

Data  20 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50269948   

TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+3nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair

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Date in BDB:
2/7/2020
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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant FAK (410 to 689 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

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Date in BDB:
6/24/2023
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TargetMitogen-activated protein kinase 14(Human)
D3R/Abbott

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair

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Date in BDB:
2/19/2023
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TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataKd:  72nMAssay Description:D3R2022More data for this Ligand-Target Pair

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2/19/2023
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TargetVascular endothelial growth factor receptor 2(Human)
D3R/Abbott

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataKd:  1.40E+3nMAssay Description:D3R2021More data for this Ligand-Target Pair

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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Inhibition of GST-FAK domain (410-689) (unknown origin)More data for this Ligand-Target Pair

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3/23/2022
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TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK1/cyclinBMore data for this Ligand-Target Pair

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3/23/2022
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TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK7/cyclinH/MAT1More data for this Ligand-Target Pair

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3/23/2022
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TargetProtein-tyrosine kinase 2-beta(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Pyk2 (unknown origin)More data for this Ligand-Target Pair

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3/23/2022
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TargetGlycogen synthase kinase-3 beta(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair

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3/23/2022
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TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+3nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair

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Date in BDB:
4/25/2021
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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant FAK (410 to 689 residues) (unknown origin) using Poly (4:1 Glu, Tyr) peptide as substrate enzyme pretreated with substrate ...More data for this Ligand-Target Pair

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Date in BDB:
2/21/2021
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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human A431 cells by ELISAMore data for this Ligand-Target Pair

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1/11/2010
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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair

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4/13/2014
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TargetGlycogen synthase kinase-3 beta(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair

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1/11/2010
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TargetCyclin-dependent kinase 7(Human)
University of Virginia

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 197nMAssay Description:Inhibition of human CDK7/cyclinH/MAT1More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 1(Human)
University of Virginia

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 486nMAssay Description:Inhibition of human CDK1/cyclinBMore data for this Ligand-Target Pair

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TargetProtein-tyrosine kinase 2-beta(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Pyk2More data for this Ligand-Target Pair

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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair

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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human FG cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair

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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 300nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human L3.6pl cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair

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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 50nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human SKOV3 cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair

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TargetFocal adhesion kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50269948(PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Inhibition of FAK Tyr397 phosphorylation in human PC3 cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair

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