BDBM50282865 2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one::CHEMBL299784::PD120339

SMILES ClCN1C(=O)c2ccccc2S1(=O)=O

InChI Key InChIKey=RFAHYFCQZDZXLP-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50282865   

TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50282865(2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-be...)
Affinity DataIC50: 2.00E+4nMAssay Description:Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50282865(2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-be...)
Affinity DataIC50: 2.00E+4nMAssay Description:Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetNeutrophil elastase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282865(2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-be...)
Affinity DataKi:  1.80nMAssay Description:Potency of Inhibition of human leukocyte elastase (HLE) expressed as apparent binding constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article