BDBM50208823 6,11-dihydrothiochromeno[4,3-b]indole::CHEMBL180917::PD-146176

SMILES C1Sc2ccccc2-c2[nH]c3ccccc3c12

InChI Key InChIKey=ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50208823   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | PD-146176 ...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of 15LOX in rabbit reticulocytes by EIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | PD-146176 ...)
Affinity DataIC50: 810nMAssay Description:Inhibition of human 12/15-LOX expressed in HEK293 cells after 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Rabbit)
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | PD-146176 ...)
Affinity DataIC50: 3.81E+3nMAssay Description:Inhibition of rabbit reticulocyte 15-LOX using [14C]-linoleic acid as substrate preincubated for 15 mins followed by substrate addition by RP-HPLC an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | PD-146176 ...)
Affinity DataKi:  3.81E+3nMAssay Description:Competitive inhibition of human 15-LOX1 using linoleic acid as substrate after 10 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50208823(6,11-dihydrothiochromeno[4,3-b]indole | PD-146176 ...)
Affinity DataKi:  3.81E+3nMAssay Description:Competitive inhibition of human 15-LOX-1 assessed as reduction in conversion of linoleic acid to 13(S)-HpODE incubated for 10 mins followed by linole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2018
Entry Details Article
PubMed