BDBM50005795 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL285627::PD-119229-2

SMILES Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1

InChI Key InChIKey=HANOSGYMKMNFON-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50005795   

TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataIC50: 69.4nMAssay Description:Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataIC50: 170nMAssay Description:Inhibitory activity against Purine nucleoside phosphorylase evaluated by radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataIC50: 160nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataKi:  20.7nMAssay Description:Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataKi:  35.7nMAssay Description:Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataKi:  67nMAssay Description:Tested for its inhibitory activity against human erythrocytic purine nucleoside phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetPurine nucleoside phosphorylase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50005795(CHEMBL285627 | PD-119229-2 | 2,8-Diamino-9-thiophe...)
Affinity DataKi:  67nMAssay Description:Ability to inhibit purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed