BDBM50001922 2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; hydrochloride::Albalon::CHEMBL1706::NAPHAZOLINE HYDROCHLORIDE::Nafazair::Naphazoline::Naphazoline Nitrate::Naphcon forte::Opcon::Vasocon::cid_11079

SMILES C(C1=NCCN1)c1cccc2ccccc12

InChI Key InChIKey=CNIIGCLFLJGOGP-UHFFFAOYSA-N

Data  17 KI  5 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50001922   

TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50: <5.01E+3nMAssay Description:Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataIC50: 410nMAssay Description:Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.2 nM) to rat isolated brain membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataIC50: 4.80nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50:  55nMAssay Description:Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2016
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50: <5.01E+3nMAssay Description:In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as fu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50:  63nMAssay Description:In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50: <5.01E+3nMAssay Description:In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50: <5.01E+3nMAssay Description:Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50:  63nMAssay Description:Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50: >2.99E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataIC50: 1.15E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataEC50:  140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataIC50: 2.99E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetAlpha-2C adrenergic receptor(Human)
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2018
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]clonidine from alpha-adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  5.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  6.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Mouse)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  11.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Mouse)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  17.0nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  20.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetNischarin(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  122nMAssay Description:Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2ARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  245nMAssay Description:Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetAlpha-2C adrenergic receptor(Human)
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  407nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi:  407nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed