BDBM50225508 CHEBI:31401::Cilostazol::OPC-13013::OPC-21::Pletal

SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1

InChI Key InChIKey=RRGUKTPIGVIEKM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50225508   

LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 190nMAssay Description:Inhibition of low Km cAMP phosphodiesterase PDE III of human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 9.12E+4nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human platelet PDE3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Shiraz University

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The Baruch S. Blumberg Institute

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant PDE3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed