BDBM50060917 ON-01910::Rigosertib

SMILES COc1ccc(cc1NCC(=O)O)CS(=O)(=O)/C=C/c2c(cc(cc2OC)OC)OC

InChI Key InChIKey=OWBFCJROIKNMGD-UHFFFAOYSA-N

Data  13 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50060917   

TargetSerine/threonine-protein kinase PLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant Plk1 (unknown origin) preincubated for 30 mins before recombinant Cdc25C substrate addition by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50060917(ON-01910 | Rigosertib)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed