BDBM50433562 CHEMBL1818538::Nutlin-1

SMILES COc1ccc(C2=NC(C(N2C(=O)N2CCN(CC2)C(C)=O)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

InChI Key InChIKey=IYDMGGPKSVWQRT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50433562   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50433562(Nutlin-1 | CHEMBL1818538)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human GST-tagged MDM2 assessed as inhibition of binding to full length p53More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50433562(Nutlin-1 | CHEMBL1818538)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant p53 protein binding to recombinant human MDM2 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed