BDBM50386381 Nucynta::TAPENTADOL HYDROCHLORIDE::Tapentadol

SMILES CC[C@H]([C@@H](C)CN(C)C)c1cccc(O)c1

InChI Key InChIKey=KWTWDQCKEHXFFR-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50386381   

TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50386381(Nucynta | Tapentadol | TAPENTADOL HYDROCHLORIDE)
Affinity DataEC50:  670nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50386381(Nucynta | Tapentadol | TAPENTADOL HYDROCHLORIDE)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50386381(Nucynta | Tapentadol | TAPENTADOL HYDROCHLORIDE)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK-293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed