BDBM50453799 Niguldipine

SMILES COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1

InChI Key InChIKey=SVJMLYUFVDMUHP-UHFFFAOYSA-N

Data  16 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50453799   

TargetATP-dependent translocase ABCB1(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataIC50: 708nMAssay Description:Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50453799(Niguldipine)
Affinity DataEC50:  750nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards recombinant human alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  0.380nMAssay Description:Binding affinity towards Alpha-1A adrenergic receptor in bovine brain using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Prestwick Chemical

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  1.80nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1A adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  4.60nMAssay Description:Binding affinity for rat L-type [Ca2+] channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  6.40nMAssay Description:Binding affinity towards Alpha-1A adrenergic receptor in rat hippocampal membranes using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  9nMAssay Description:Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  25nMAssay Description:Binding affinity towards Alpha-1B adrenergic receptor hamster smooth muscle using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  82nMAssay Description:Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  85nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  191nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  295nMAssay Description:Binding affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  370nMAssay Description:Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  380nMAssay Description:Binding affinity towards Alpha-1B adrenergic receptor in rat liver using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  645nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hypocampus membrane using [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed