BDBM82376 CAS_80880-90-6::NSC_5387::TELENZEPINE

SMILES CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc3ccccc23)CC1

InChI Key InChIKey=VSWPGAIWKHPTKX-UHFFFAOYSA-N

Data  12 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 82376   

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataIC50: 3.15E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  1.29nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  1.80nMAssay Description:Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Chicken)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  2.45nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor(Rabbit)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  2.63nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Bovine)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  5.88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  6.90nMAssay Description:Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  7.59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor(Pig)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  12.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  17.0nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  17nMAssay Description:Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M4 of NG108-15 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  50nMAssay Description:The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM82376(NSC_5387 | CAS_80880-90-6 | TELENZEPINE)
Affinity DataKi:  67.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed