BDBM81467 CAS_569-65-3::CHEMBL1085765::Meclizine::NSC_4034::US9182402, 13

SMILES Cc1cccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)c1

InChI Key InChIKey=OCJYIGYOJCODJL-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 81467   

TargetSerine protease hepsin(Human)
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM81467(CHEMBL1085765 | NSC_4034 | CAS_569-65-3 | Meclizin...)
Affinity DataIC50: 2.02E+3nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetTrypsin(Pig)
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM81467(CHEMBL1085765 | NSC_4034 | CAS_569-65-3 | Meclizin...)
Affinity DataIC50: 2.00E+4nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetProthrombin(Bovine)
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM81467(CHEMBL1085765 | NSC_4034 | CAS_569-65-3 | Meclizin...)
Affinity DataIC50: 2.00E+4nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM81467(CHEMBL1085765 | NSC_4034 | CAS_569-65-3 | Meclizin...)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM81467(CHEMBL1085765 | NSC_4034 | CAS_569-65-3 | Meclizin...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in presence of 0.01% Triton X-100More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM81467(CHEMBL1085765 | NSC_4034 | CAS_569-65-3 | Meclizin...)
Affinity DataKi:  250nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed