BDBM86282 6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide::CAS_1218::CHEMBL553503::NSC_1218::SKF 81297::cid_11957706

SMILES Oc1cc2C(CNCCc2c(Cl)c1O)c1ccccc1

InChI Key InChIKey=GHWJEDJMOVUXEC-UHFFFAOYSA-N

Data  9 KI  3 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 86282   

TargetGalanin receptor type 3(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataIC50: 3.83E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  1.78E+3nMAssay Description:Agonist activity at N-terminal Flag epitope tagged human dopamine D1 receptor expressed in HTLA cells assessed as beta-arrestin translocation activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  4.70nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  360nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  9.50E+3nMAssay Description:Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetLarge T antigen(SV40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  4.10E+4nMAssay Description:Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details
PCBioAssay
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataIC50: 2.99E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50:  6.54E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataIC50: 2.99E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataEC50: >2.99E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetD(1A) dopamine receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  7nMAssay Description:The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based compe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  310nMAssay Description:The compound was evaluated for the binding affinity towards dopamine receptor D2 at high affinity state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  509nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  995nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  1.27E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi:  8.00E+3nMAssay Description:The compound was evaluated for the binding affinity towards dopamine receptor D2 at low affinity state.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86282(NSC_1218 | cid_11957706 | 6-Chloro-1-phenyl-2,3,4,...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed