BDBM86420 CAS_92623-85-3::Milnacipran::NSC_0

SMILES CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2

InChI Key InChIKey=GJJFMKBJSRMPLA-UHFFFAOYSA-N

Data  10 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 86420   

TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 64nMAssay Description:Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi:  8.44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi:  22nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi:  68nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi:  123nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi:  151nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM86420(CAS_92623-85-3 | NSC_0 | Milnacipran)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed