BDBM50478473 CHEBI:49::FANCHININ::NSC-77037::Tetrandrine

SMILES [H][C@]12Cc3ccc(Oc4cc(C[C@]5([H])N(C)CCc6cc(OC)c(OC)c(Oc7cc1c(CCN2C)cc7OC)c56)ccc4OC)cc3

InChI Key InChIKey=WVTKBKWTSCPRNU-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50478473   

TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50478473(CHEBI:49 | NSC-77037 | FANCHININ | Tetrandrine)
Affinity DataIC50: 3.00E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50478473(CHEBI:49 | NSC-77037 | FANCHININ | Tetrandrine)
Affinity DataKi:  306nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50478473(CHEBI:49 | NSC-77037 | FANCHININ | Tetrandrine)
Affinity DataKi:  461nMAssay Description:Displacement of [125I]apamin from SK3 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Universidad De Chile

Curated by ChEMBL
LigandPNGBDBM50478473(CHEBI:49 | NSC-77037 | FANCHININ | Tetrandrine)
Affinity DataKi:  692nMAssay Description:Displacement of [3H]prazosin from alpha1 adrenergic receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Universidad De Chile

Curated by ChEMBL
LigandPNGBDBM50478473(CHEBI:49 | NSC-77037 | FANCHININ | Tetrandrine)
Affinity DataKi:  741nMAssay Description:Displacement of [3H]diltiazem from benzodiazepine binding site of L-type calcium channel in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed