BDBM50049385 5-Hydroxy-2-phenyl-chromen-4-one::5-Hydroxyflavone::5-hydroxy-2-phenyl-4H-chromen-4-one::5-hydroxy-flavone::CHEMBL16807::NSC-26745

SMILES Oc1cccc2oc(cc(=O)c12)-c1ccccc1

InChI Key InChIKey=IYBLVRRCNVHZQJ-UHFFFAOYSA-N

Data  5 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50049385   

TargetAndrogen receptor(Human)
Meijo University

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSialidase-2(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human Neu2 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Meijo University

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 832nMAssay Description:Antagonist activity at human androgen receptor LBD expressed in human MDA-kb2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Meijo University

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 840nMAssay Description:Antagonist activity at human androgen receptor LBD expressed in human MDA-kb2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 310nMAssay Description:Inhibition of CYP1A2 (unknown origin)-mediated demethylation of resorufin methyl ether after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of CYP1A1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Thr129, Ser205, Hie78, Lys367, Ala366, Gly52 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataKi:  2.17E+3nMAssay Description:Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataKi:  2.19E+3nMAssay Description:Ability to displace [3H]N6-phenylisopropyladenosine binding from adenosine A1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataKi:  3.53E+3nMAssay Description:Binding affinity to PKM2 (unknown origin) assessed as oxidation of beta-NADH by spectrophotometry based LDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataKi:  6.17E+3nMAssay Description:Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-hydroxy-flavo...)
Affinity DataKi:  6.20E+3nMAssay Description:Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed