BDBM50011446 2-(4-Hydroxy-phenyl)-chromen-4-one::2-(4-hydroxyphenyl)-4H-chromen-4-one::4'-hydroxyflavone::CHEMBL327209::NSC-22357

SMILES Oc1ccc(cc1)-c1cc(=O)c2ccccc2o1

InChI Key InChIKey=SHGLJXBLXNNCTE-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50011446   

TargetTyrosine-protein kinase Lck(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50011446(NSC-22357 | 4'-hydroxyflavone | 2-(4-hydroxyphenyl...)
Affinity DataIC50: 5.04E+5nMAssay Description:Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50011446(NSC-22357 | 4'-hydroxyflavone | 2-(4-hydroxyphenyl...)
Affinity DataIC50: 4.19E+5nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCholinesterase(Human)
Julius Maximilian University Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50011446(NSC-22357 | 4'-hydroxyflavone | 2-(4-hydroxyphenyl...)
Affinity DataIC50: 304nMAssay Description:Inhibition of human BChE using acetylthiocholine iodide as substrate incubated for 20 to 60 mins followed by substrate addition by spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Julius Maximilian University Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50011446(NSC-22357 | 4'-hydroxyflavone | 2-(4-hydroxyphenyl...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 to 60 mins followed by substrate addition by spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Birla Institute of Technology

LigandPNGBDBM50011446(NSC-22357 | 4'-hydroxyflavone | 2-(4-hydroxyphenyl...)
Affinity DataKi:  1.05E+3nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Birla Institute of Technology

LigandPNGBDBM50011446(NSC-22357 | 4'-hydroxyflavone | 2-(4-hydroxyphenyl...)
Affinity DataKi:  5.06E+3nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed