BDBM50219487 1-hydroxy-2-naphthoate::1-hydroxy-2-naphthoic acid::CHEMBL229299::LDHA Inhibitor, 5::NSC 3717::Xinafoic acid

SMILES c1ccc2c(c1)ccc(c2O)C(=O)O

InChI Key InChIKey=SJJCQDRGABAVBB-UHFFFAOYSA-N

Data  4 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50219487   

TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50219487(CHEMBL229299 | LDHA Inhibitor, 5 | 1-hydroxy-2-nap...)
Affinity DataIC50: 5.00E+5nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50219487(CHEMBL229299 | LDHA Inhibitor, 5 | 1-hydroxy-2-nap...)
Affinity DataKd:  6.40E+5nMpH: 7.5 T: 2°CAssay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Inha University

Curated by ChEMBL
LigandPNGBDBM50219487(CHEMBL229299 | LDHA Inhibitor, 5 | 1-hydroxy-2-nap...)
Affinity DataIC50: 8.50E+5nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50219487(CHEMBL229299 | LDHA Inhibitor, 5 | 1-hydroxy-2-nap...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of influenza A/WSN/1933 (H1N1) virus neuraminidase N1 using MUNANA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50219487(CHEMBL229299 | LDHA Inhibitor, 5 | 1-hydroxy-2-nap...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Influenza A virus A/WSN/1933(H1N1)) neuraminidase in the presence of 2'-(4-methyl-umbelliferyl)-alphaD-N-acetylneuraminic acid substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed