BDBM50049744 CHEMBL438548::NPY-analogs::[Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2

SMILES CCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CSSC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O

InChI Key InChIKey=QUIHYEFPGVPGCQ-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50049744   

TargetNeuropeptide Y receptor type 4(Human)
University of Cincinnati

Curated by ChEMBL
LigandPNGBDBM50049744([Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 | NPY-analogs | CHE...)
Affinity DataEC50:  570nMAssay Description:Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 4(Human)
University of Cincinnati

Curated by ChEMBL
LigandPNGBDBM50049744([Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 | NPY-analogs | CHE...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]hPP from human NPY4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50049744([Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 | NPY-analogs | CHE...)
Affinity DataKi:  46nMAssay Description:Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Cincinnati Medical Center

Curated by ChEMBL
LigandPNGBDBM50049744([Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 | NPY-analogs | CHE...)
Affinity DataKi:  340nMAssay Description:Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
University of Cincinnati

Curated by ChEMBL
LigandPNGBDBM50049744([Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 | NPY-analogs | CHE...)
Affinity DataKi: >3.00E+3nMAssay Description:Agonist activity at human NPY2 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
University of Cincinnati

Curated by ChEMBL
LigandPNGBDBM50049744([Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 | NPY-analogs | CHE...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for the displacement of [125I]-PYY(3-36) (SK-N-BE2) from Neuropeptide Y receptor type 2 in the membranes prepared from cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed