BDBM50226181 (3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-enyl)benzamido)-2-oxo-2H-chromen-7-yloxy)-3-methoxy-2,2-dimethyl-tetrahydro-2H-pyran-4-yl carbamate::(3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-enyl)benzamido)-8-methyl-2-oxo-2H-chromen-7-yloxy)-3-methoxy-2,2-dimethyl-tetrahydro-2H-pyran-4-yl carbamate::CHEMBL36506::Carbamic acid (3R,4S,5R,6R)-5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-3-(3-methyl-but-2-enyl)-benzoylamino]-8-methyl-2-oxo-2H-chromen-7-yloxy}-3-methoxy-2,2-dimethyl-tetrahydro-pyran-4-yl ester::Carbamic acid (3R,4S,5R,6R)-5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-3-(4-methyl-pent-3-enyl)-benzoylamino]-8-methyl-2-oxo-2H-chromen-7-yloxy}-3-methoxy-2,2-dimethyl-tetrahydro-pyran-4-yl ester::Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-3-(3-methyl-but-2-enyl)-benzoylamino]-8-methyl-2-oxo-2H-chromen-7-yloxy}-3-methoxy-2,2-dimethyl-tetrahydro-pyran-4-yl ester::Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-3-(3-methyl-but-2-enyl)-benzoylamino]-8-methyl-2-oxo-2H-chromen-7-yloxy}-3-methoxy-2,2-dimethyl-tetrahydro-pyran-4-yl ester(Novobiocin)::NOVOBIOCIN

SMILES [#6]-[#8]-[#6@@H]1-[#6@@H](-[#8]-[#6](-[#7])=O)-[#6@@H](-[#8])-[#6@H](-[#8]-c2ccc3c(-[#8])c(-[#7]-[#6](=O)-c4ccc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6])c4)c(=O)oc3c2-[#6])-[#8]C1([#6])[#6]

InChI Key InChIKey=BKRYLNPFZBMBFV-UHFFFAOYSA-N

Data  4 KI  62 IC50  4 Kd  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 79 hits for monomerid = 50226181   

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling incubated for 30 mins in presence of ATP by ethidium bromide staining based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataKi:  7nMAssay Description:Inhibition of Escherichia coli H560 DNA gyrase B ATPase activity after 30 mins by ammonium molybdate/malachite green-based phosphate detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2018
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataKd:  7nMAssay Description:Binding affinity to Escherichia coli H560 DNA gyrase BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2018
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as supercoiling of relaxed pBR322 plasmid after 45 mins by ethidium bromide staining based ag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pBR322 DNA as substrate after 3 hrs by DNA super-coiling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase ATPase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Escherichia coli DNA gyrase ATPase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 24nMAssay Description:Inhibition of Escherichia coli DNA gyrase by measuring supercoiling activity incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase-mediated supercoiling of relaxed DNA using pBR 322 as substrate by agarose gel electrophoresis analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pNO1 plasmid and biotinylated oligonucelotide incubated for 30 mins by fluorescence base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as supercoiling of relaxed pNO1 plasmid after 30 mins by SybrGOLD staining based fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using biotinylated oligonucleotide as substrate incubated for 30 mins in presence of ATP by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B preincubated for 10 mins followed by ATP addition measured after 30 mins by purine nucleoside phosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase A/DNA gyrase B supercoiling activity using relaxed pNO1 DNA as substrate after 30 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B using relaxed pNO1 DNA as substrate incubated for 30 mins and measured by sybrGOLD staining based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 46nMAssay Description:Inhibition of Mycobacterium smegmatis 155 6His-tagged DNA gyrase B catalytic domain ATPase activity expressed in Escherichia coli BL21 (DE3) pLysS ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2018
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 46nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 80nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed pBR322 DNA as substrate after 3 hrs by DNA super-coiling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 85nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 125nMAssay Description:Inhibition of Staphylococcus aureus N-terminal His6-tagged DNA gyrase subunit GyrA/GyrB supercoiling activity expressed in Escherichia coli BL21 (DE3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2020
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 125nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATPase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 168nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA gyrase B using relaxed pNO1 DNA as substrate incubated for 30 mins and measured by sybrGOLD staining ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence of b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli C-terminal His6-tagged DNA gyrase B expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DNA gyrase using biotinylated oligonucleotide as substrate incubated for 30 mins in presence of ATP by fluorescence-ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed pNO1 plasmid and biotinylated oligonucelotide incubated for 30 mins by fluorescence based DNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduction in ATPase activity incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Birla Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of 6-His-tagged Mycobacterium smegmatis GyrB expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 100 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 408nMAssay Description:Inhibitory activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2018
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 408nMAssay Description:Inhibitory activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2018
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 408nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 408nMAssay Description:Iinhibitory activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 457nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Mansoura University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDNA gyrase subunit A(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
John Innes Centre

LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Mycobacterium tuberculosis gyrase supercoiling, relaxation, and decatenation assays were carried out as described previously.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2013
Entry Details Article
PubMed
TargetMicrotubule-associated proteins 1A/1B light chain 3A(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataKd:  7.50E+3nMAssay Description:Binding affinity to human LC3A expressed in Escherichia coli BL21-(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Chinese Academy of Medical Sciences&Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of Staphylococcus aures ParE using pBR322 DNA as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMicrotubule-associated proteins 1A/1B light chain 3A(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataKi:  8.80E+3nMAssay Description:Displacement of sGFP-p62-LIR peptide from human N-terminal SNAP-fused LC3A by time-resolved FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetTopoisomerase IV(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 decatenation incubated for 30 mins in presence of ATP by ethidium bromide staining based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMicrotubule-associated proteins 1A/1B light chain 3B(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50226181BDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataKd:  1.74E+4nMAssay Description:Binding affinity to human LC3B expressed in Escherichia coli BL21-(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
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