BDBM50071754 (S)-2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide::CHEMBL86828::NMB::Xenopus NMB

SMILES CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(CCCCC1)c1ccccn1

InChI Key InChIKey=RVCSRPVACXMJEL-UHFFFAOYSA-N

Data  17 KI  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50071754   

TargetNeuromedin-B receptor(Rat)
TBA

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataIC50: 150nMAssay Description:Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2012
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TargetNeuromedin-B receptor(Human)
Tularik

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataIC50: 350nMAssay Description:Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
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TargetNeuromedin-B receptor(Rat)
TBA

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
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TargetNeuromedin-B receptor(Human)
Tularik

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  6.30nMAssay Description:Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Ph...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2012
Entry Details Article
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TargetNeuromedin-B receptor(Human)
Tularik

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  6.30nMAssay Description:Binding affinity against human NMB receptor was determinedMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2012
Entry Details Article
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TargetNeuromedin-B receptor(Human)
Tularik

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  6.30nMAssay Description:Binding affinity against human NMB receptor was determinedMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2012
Entry Details Article
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TargetBombesin(frogs and toads)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  11nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
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TargetBombesin(frogs and toads)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  11nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
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TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  100nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  127nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  134nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  174nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGastrin-releasing peptide receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  180nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGastrin-releasing peptide receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  248nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetNeuromedin-B receptor(Rat)
TBA

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  340nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetBombesin receptor subtype-3(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  4.80E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetBombesin receptor subtype-3(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP K_i Database

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi:  7.10E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/12/2012
Entry Details Article
Copy Entry DOIPubMed
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TargetGastrin-releasing peptide receptor(Human)
TBA

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human GRP(gastrin releasing peptide) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/26/2012
Entry Details Article
Copy Entry DOI
Copy Rxn URL

TargetGastrin-releasing peptide receptor(Human)
TBA

Curated by ChEMBL

LigandBDBM50071754(Xenopus NMB | CHEMBL86828 | NMB | (S)-2-[3-(2,6-Di...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL