BDBM50135912 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin::5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione::CHEMBL1274::NILUTAMIDE

SMILES CC1(C)NC(=O)N(C1=O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI Key InChIKey=XWXYUMMDTVBTOU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50135912   

TargetAndrogen receptor(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50135912(5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 9nMAssay Description:Inhibition of [3H]mibolerone binding to human Androgen receptor of PC3/AR Cell LysateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50135912(5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 9nMAssay Description:Inhibition of 1.0 nM [3H]mibolerone binding to human androgen receptor of PC3/AR cell lysateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50135912(5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 600nMAssay Description:Inhibition of wild-type androgen receptor in human LAPC4 cells assessed as inhibition of DHT-induced luciferase activity measured after 24 hrs by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50135912(5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Androgen receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed