BDBM50152808 (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[(2-thiophen-2-yl-ethylamino)-methyl]-phenyl}-piperazin-1-yl)-ethyl]-amide::(R)-N-((R)-3-(4-chlorophenyl)-1-oxo-1-(4-(2-((2-(thiophen-2-yl)ethylamino)methyl)phenyl)piperazin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarboxamido]-3-(4-chlorophenyl)propionyl-1-[2[2-(2-thienyl)-ethylaminomethyl]methyl]phenyl piperazine::CHEMBL366706::NBI-55886

SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2CNCCc2cccs2)cc1

InChI Key InChIKey=JSSBJZNAQLSMID-UHFFFAOYSA-N

Data  9 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50152808   

TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataEC50:  357nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  9.55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  11nMAssay Description:Displacement of [125]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards human melanocortin 4 receptor expressed in HEK 293 cells using [125I]NDP-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  11nMAssay Description:Binding affinity to human MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  12nMAssay Description:Tested for inhibition of binding to MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  240nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808(4-(2R)-[(3R)-1,2,3,4-tetrahydroisoquinolinylcarbox...)
Affinity DataKi:  6.00E+3nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed