BDBM22530 N(alpha)-Methylhistamine::N-alpha-methylhistamine::N-methylhistamine::NAMH::[2-(1H-imidazol-5-yl)ethyl](methyl)amine::[3H]N-alpha-methyl histamine

SMILES CNCCc1cnc[nH]1

InChI Key InChIKey=PHSPJQZRQAJPPF-UHFFFAOYSA-N

Data  19 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 22530   

TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at human histamine H3 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  0.390nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  1.99nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  4nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH3R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  5.01nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetHistamine H3 receptor(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  19nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Glaxo Research & Development

Curated by PDSP Ki Database
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  316nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi:  316nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | [2-(1H-imidazol-5-yl)et...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2012
Entry Details
PubMed