BDBM50367061 NALORPHINE::NALORPHINE HYDROCHLORIDE

SMILES O[C@H]1C=C[C@H]2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45

InChI Key InChIKey=UIQMVEYFGZJHCZ-UHFFFAOYSA-N

Data  8 KI  13 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50367061   

LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataEC50:  1.5nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]-naloxone from rat opioid receptor after 30 mins by liquid scintillation counting analysis in presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]-naloxone from rat opioid receptor after 30 mins by liquid scintillation counting analysis in absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataEC50:  1.5nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataEC50:  1.5nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 2.85E+3nMAssay Description:Inhibition of specific binding of [3H]3-PPP to sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of specific binding of [125I]-PIPAG to sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 735nMAssay Description:Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 48nMAssay Description:Inhibition of specific binding of [3H]NANM of sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 625nMAssay Description:Inhibition of specific binding of [3H]DTG to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 93nMAssay Description:Inhibition of specific binding of [3H]3-PPP to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of specific binding of [3H]DTG to sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 28nMAssay Description:Evaluated the ability to protect against the irreversible antagonism of morphines effects by beta-FNA in guinea pig ileal longitudinal muscle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 59nMAssay Description:Concentration required to inhibit the stereospecific [3H]diprenorphine binding Opioid receptors in the absence of sodium(Na+) was determined in mouse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2018
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 160nMAssay Description:Concentration required to inhibit the stereospecific [3H]diprenorphine binding Opioid receptors in the presence of sodium(Na+) was determined in mous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of specific binding of [3H]NANM of sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  0.190nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  0.380nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  2nMAssay Description:Compound administered subcutaneously was evaluated for inhibition constant measured as the displacement of [3H]DAGO from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  2nMAssay Description:Binding affinity to human kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  6.5nMAssay Description:Binding affinity to Opioid receptor mu 1 in rat brain using [3H]-NAL as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  15nMAssay Description:Binding affinity to Opioid receptor kappa 1 in guinea pig cortex using [3H]EKC as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed