BDBM525256 (H)Arg-Glu-Phe-Arg-kbt::N-0438

SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1

InChI Key InChIKey=HENHNGFKMLDXRP-UHFFFAOYSA-N

Data  6 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 525256   

TargetTransmembrane protease serine 2(Human)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataIC50: 5.20nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataEC50:  36nMAssay Description:Intracellular dose response (EC50 values) for selected compounds against SARS-CoV-2 were determined by pre-treating Calu-3 cells for three hr with se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataKi:  0.520nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataKi:  1.11nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataKi:  31nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataKi:  7.72E+3nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProthrombin(Human)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataKi: >1.00E+4nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetFurin(Human)
University of British Columbia

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataKi: >1.00E+4nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed