BDBM50458158 Mk-0752

SMILES c1cc(ccc1S(=O)(=O)C2(CCC(CC2)CCC(=O)O)c3cc(ccc3F)F)Cl

InChI Key InChIKey=XCGJIFAKUZNNOR-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50458158   

TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50458158(Mk-0752)
Affinity DataIC50: 55nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as notch cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50458158(Mk-0752)
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma secretase in human MCF7 cells assessed as reduction in amyloid beta 40 after 3 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)