BDBM50530214 CHEBI:82937::Leriglitazone::Min-102::US20240091210, Compound MIN-102::US20250064791, Compound MIN-102

SMILES CC(O)c1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1

InChI Key InChIKey=OXVFDZYQLGRLCD-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 Kd  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50530214   

TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of FITC-NCoR1 peptide from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataEC50:  680nMAssay Description:Transactivation of full length human PPARgamma2 expressed in HEK293T cells co-expressing PPRE after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataEC50:  1.30E+3nMAssay Description:Transactivation of chimeric Gal4 yeast DBD fused-PPARgamma LBD (unknown origin) expressed in HEK293T cells co-expressing PPRE after 18 hrs by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of FITC-NCoR1 peptide from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia coli BL21(DE3) after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataKd:  708nMAssay Description:Binding affinity to human 6His-tagged PPARgamma LBD expressed in Escherichia coli BL21(DE3) using FITC-NTKNHPMLMNLLKDNPAQD peptide by isothermal titr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataEC50:  680nMAssay Description:Transactivation of full length human PPARgamma2 expressed in HEK293T cells co-expressing PPRE after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataEC50:  1.30E+3nMAssay Description:Transactivation of chimeric Gal4 yeast DBD fused-PPARgamma LBD (unknown origin) expressed in HEK293T cells co-expressing PPRE after 18 hrs by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataEC50:  2.10E+3nMAssay Description:Activation of human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia coli BL21(DE3) assessed as increase in FITC-TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataEC50:  2.10E+3nMAssay Description:Activation of human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia coli BL21(DE3) assessed as increase in FITC-TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataKd:  708nMAssay Description:Binding affinity to human 6His-tagged PPARgamma LBD expressed in Escherichia coli BL21(DE3) using FITC-NTKNHPMLMNLLKDNPAQD peptide by isothermal titr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMitochondrial pyruvate carrier 1/2(Human)
Minoryx Therapeutics

US Patent
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataIC50: 4.10E+3nMAssay Description:The MPC is a heterodimer composed of two subunits, MPC1 and MPC2. MPC1 and MPC2 interact to form an active carrier. In the assay, MPC2 was fused to R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent

TargetMitochondrial pyruvate carrier 1/2(Human)
Minoryx Therapeutics

US Patent
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataIC50: 4.10E+3nMAssay Description:The MPC is a heterodimer composed of two subunits, MPC1 and MPC2. MPC1 and MPC2 interact to form an active carrier. In the assay, MPC2 was fused to R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2025
Entry Details
Go to US Patent

TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of fluormone PanPPAR green tracer ligand from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530214(CHEBI:82937 | Leriglitazone | Min-102 | US20240091...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of fluormone PanPPAR green tracer ligand from human 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed