BDBM16179 4-{[5-({[(3S)-1-(3-chlorobenzyl)-2-oxopyrrolidin-3-yl]amino}methyl)-1H-imidazol-1-yl]methyl}benzonitrile::4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]amino}methyl)-1H-imidazol-1-yl]methyl}benzonitrile::CHEMBL312137::MSD-1

SMILES Clc1cccc(CN2CC[C@H](NCc3cncn3Cc3ccc(cc3)C#N)C2=O)c1

InChI Key InChIKey=VYLMFRUDZGQCNT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 16179   

TargetATP-dependent RNA helicase RhlE(Vibrio fischeri (strain ATCC 700601 / ES114))
University of Washington At Seattle

LigandPNGBDBM16179(4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrr...)
Affinity DataIC50: 64nMAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2007
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16179(4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrr...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory concentration of geranylgeranyl-protein transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16179(4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrr...)
Affinity DataIC50: 0.520nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16179(4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrr...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of farnesyl transferase using purified recombinant human enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16179(4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrr...)
Affinity DataIC50: 440nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed