BDBM50085683 (+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole::4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole::CHEMBL778::DEXMEDETOMIDINE::MPV 1440::US20250032476, Compound DEX

SMILES C[C@H](c1cnc[nH]1)c1cccc(C)c1C

InChI Key InChIKey=CUHVIMMYOGQXCV-UHFFFAOYSA-N

Data  9 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50085683   

TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  0.0150nMAssay Description:In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  0.0150nMAssay Description:Binding affinity towards alpha-2D adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  0.0150nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  0.0150nMAssay Description:In vitro binding affinity against alpha-2 adrenergic receptor in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  5nMAssay Description:Tested for Binding affinity towards alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  5nMAssay Description:in vitro alpha-2A adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  10nMAssay Description:Competition binding with α2AR subtypes were performed by incubating membranes in buffer A (50 mM TRIS at pH 7.4) at final protein concentrations of 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetAlpha-2C adrenergic receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]RX 821002 from human adrenergic alpha-2c receptor expressed in CHO cells in presence of GppNHp/NaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed