BDBM50531952 Elbasvir::MK-8742

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc(c[nH]1)-c1ccc2-c3cc4cc(ccc4n3[C@@H](Oc2c1)c1ccccc1)-c1c[nH]c(n1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key InChIKey=BVAZQCUMNICBAQ-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50531952   

TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A in HCV genotype 1b assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  0.0200nMAssay Description:Inhibition of NS5A in HCV genotype 3a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A in HCV genotype 2a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  2nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50531952(Elbasvir | MK-8742)
Affinity DataEC50:  3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed