BDBM50003020 MK-3102::OMARIGLIPTIN::US10155775, Omarigliptin::US10479798, Compound MK3102::US10822319, Compound Omarigliptin::US20240115577, Compound 9

SMILES CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F

InChI Key InChIKey=MKMPWKUAHLTIBJ-UHFFFAOYSA-N

Data  1 KI  18 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50003020   

TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to DPP4 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 0.800nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant DPP4 incubated for 15 mins using Gly-Pro-7-AMC substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 4.20nMAssay Description:a. White 384-well plate (Perkin Elmer, Catalog No. 607290/99)b. HEPES buffer: using 1M HEPES buffer (Invitrogen, Catalog No. 15630-080) to prepare 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 2nMAssay Description:Screening Method:Name of method: Activity Evaluation of DPP4, Fluorescence.Instrument: Microplate reader, Envision (PerkinElmer, USA).Material: human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 4.20nMAssay Description:1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of DPP4 (unknown origin) expressed in Sf9 cells using Gly-Pro-AMC substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 1.60nMAssay Description:Competitive reversible inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by MK-499 displacement binding analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 44nMAssay Description:Inhibition of DPP4 in mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of PEP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of FAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of QPP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataKi:  0.800nMAssay Description:Competitive reversible inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed