BDBM50296579 3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyclopentyl]amino}-methyl)-4-methyl-1H-pyrazol-1-yl]propanenitrile::CHEMBL560667::MK-1925

SMILES Cc1c(CN[C@H]2CC[C@@H](F)C2)nn(CCC#N)c1-c1cc(F)cc(F)c1

InChI Key InChIKey=LJTOZIFFXNLWEQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50296579   

TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: 8.20nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naltrindole from human cloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: 9.50E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: 4.60nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]diprenorphin from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296579(3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyc...)
Affinity DataIC50: 9.80E+3nMAssay Description:Displacement of [3H]U69593 from human cloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed