BDBM50360601 CHEMBL1933349::MK-0893

SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=DNTVJEMGHBIUMW-UHFFFAOYSA-N

Data  1 KI  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50360601   

TargetVasoactive intestinal polypeptide receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.28E+4nMAssay Description:Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 2.43E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 20nMAssay Description:Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHOK1 cells after 3 hrs by micro beta scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2E1 in liver microsomes assessed as chlorzoxazone 6beta-hydroxylation after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human CYP2B6 in liver microsomes assessed as bupropion hydroxylation after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of human CYP1A2 in liver microsomes assessed as phenacetin O-deethylation after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human CYP2C9 in liver microsomes assessed as diclofenac 4'-hydroxylation after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human CYP2C8 in liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 in liver microsomes assessed as dextromethorphan O-demethylation after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human CYP3A4 in liver microsomes assessed as testosterone 6beta-hydroxylation after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVasoactive intestinal polypeptide receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.16E+4nMAssay Description:Antagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins pri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 9.20E+3nMAssay Description:Antagonist activity at human PAC1 expressed in mouse HIN 3T3 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human GLP1R expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 727nMAssay Description:Antagonist activity at rat GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 122nMAssay Description:Antagonist activity at mouse GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetUncharacterized protein [173-650](Dog)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 105nMAssay Description:Antagonist activity at dog GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon receptor [1-477](Rhesus macaque)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 56nMAssay Description:Antagonist activity at rhesus monkey GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 1.02E+3nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50: 6.60nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 3 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataKi:  70nMAssay Description:Displacement of [125I]Glucagon-Cex from human GCGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed