BDBM50273099 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole::3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole::CHEMBL456145::MK-0354

SMILES C1Cc2[nH]nc(c2C1)-c1nnn[nH]1

InChI Key InChIKey=LTQYSJKGRPGMPO-UHFFFAOYSA-N

Data  1 KI  4 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50273099   

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  1.65E+3nMAssay Description:Agonist activity against human GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity against mouse GPR109a assessed as forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity against human GPR109a assessed as GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  400nMAssay Description:Agonist activity against mouse GPR109a assessed as GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity against rat GPR109a assessed as GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  286nMAssay Description:Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR10a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [3H]nicotinic acid from human GPR10a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR109a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataEC50:  286nMAssay Description:Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(MK-0354 | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydroc...)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed