BDBM50117922 (1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl 2-methoxyacetate::2-{2-[3-(1H-benzoimidazol-2-yl)-propylamino]-ethyl}-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester(Mibefradil)Methoxy-acetic acid::CHEMBL45816::MIBEFRADIL::Methoxy-acetic acid (1S,2S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester::Methoxy-acetic acid 2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester::Mibefradil dihydrochloride

SMILES CC(C)[C@H]1c2ccc(cc2CC[C@@]1(CCN(C)CCCc3[nH]c4ccccc4n3)OC(=O)COC)F

InChI Key InChIKey=HBNPJJILLOYFJU-UHFFFAOYSA-N

Data  4 KI  75 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 80 hits for monomerid = 50117922   

TargetATP-dependent translocase ABCB1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.43E+3nMAssay Description:K+ channel blocking activity in COS-7 African green monkey kidney derived cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 830nMAssay Description:Inhibition of alpha-1G calcium channel in human HEK293 cells by whole-cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 860nMAssay Description:Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by IONWORKS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant CYP2D6-mediated 7-methoxy-4(aminomethyl)-coumarine degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at human alpha1H T-type calcium channel expressed in HEK293 cells by patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit and Kir2.1 potassium channel by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 300nMAssay Description:Reversible inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of T-type [Ca2+] channel (alpha1G) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 580nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of T type calcium channel Cav3.1 (unknown origin) expressed in HEK293T cells by patch clamp method relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human Cav3.1 expressed in tsA-201 cells by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human ERG by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 560nMAssay Description:Inhibition of t-type Cav3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of 50 ms depolarizing voltage step-induced curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 510nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human heart Nav1.5 expressed in HEK293 cells by whole cell voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 500nMAssay Description:Inhibition of rat brain Nav1.2 expressed in HEK293 cells by whole cell voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 250nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 64nMAssay Description:Inhibition of Cav3.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 500nMAssay Description:Inhibition of rat skeletal muscle Nav1.4 expressed in HEK293 cells by whole cell voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat Cav2.2-alpha1beta/beta3 expressed in HEK293 cells assessed as decrease in calcium mobilization response to KCl after 1 hr by Fluo-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Cav3.3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Cav3.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCalcium release-activated calcium channel protein 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 5.21E+4nMAssay Description:Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction of SERCA inhibition-induced ER release preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2018
Entry Details Article
PubMed
TargetCalcium release-activated calcium channel protein 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction in BAPTA-induced Ca2+ depletion-stimulated SOC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 830nMAssay Description:Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of T type calcium channel subunit alpha-1G expressed in HEK293 cells assessed as effect on T-type calcium currents by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 126nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Antagonist activity at T type calcium channel alpha1G expressed in HEK293 cells assessed as inhibition of peak currents by whole-cell patch-clamp met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 181nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 202nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.40E+5nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes assessed as reduction in testosterone 6beta-hydroxylation incubated for 60 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ERG expressed in HEK cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of T-type calcium channel Cav3.1 alpha-1G subunit expressed in HEK293 cells assessed as calcium current by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of T-type calcium channel Cav3.1 with alpha-1G subunit by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 806nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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