BDBM50360449 CHEMBL1215739::MG-149

SMILES CCCCCCCc1ccc(CCc2cccc(O)c2C(O)=O)cc1

InChI Key InChIKey=WBHQYBZRTAEHRR-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50360449   

TargetHistone acetyltransferase KAT5(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of human recombinant His-tagged Tip60 expressed in Escherichia coli BL21(DE3) cells using [14C]Ac-AoA and histone H4 as substrate after 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of human MOF expressed in Escherichia coli BL21(DE3) cells using [14C]AC-CoA and histone H4 as substrate after 5 mins by scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 2.71E+4nMAssay Description:The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataEC50:  1.26E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 2.71E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated histone H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of recombinant human KAT3B (1287 to 1673 residues) using histone H3 peptide and [3H]-acetyl-coA as substrates incubated for 1 hrs by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed