BDBM50232153 (1-(4-fluorophenethyl)piperidin-4-yl)(2,3-dimethoxyphenyl)methanol::(2,3-Dimethoxyphenyl)-(1-(2-p-fluorophenylethyl)-piperidine-4-yl)-methanol::CHEMBL257283::MDL 100907::MDL-100907

SMILES COc1cccc(C(O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC

InChI Key InChIKey=HXTGXYRHXAGCFP-UHFFFAOYSA-N

Data  33 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50232153   

Target5-hydroxytryptamine receptor 2C(Human)
Acadia Pharmaceuticals

LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataIC50: 540nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataIC50: 1.10nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  0.0300nM ΔG°:  -13.3kcal/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  1.86nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  1.92nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Acadia Pharmaceuticals

LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  3.80nM ΔG°:  -10.7kcal/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Acadia Pharmaceuticals

LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  30.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  66.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  128nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  261nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  425nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  1.02E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  1.44E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  1.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  2.96E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed