BDBM50666916 ENPATORAN::Enpatoran::M-5049::M5049

SMILES c1cc2c(ccc(c2nc1)C#N)N3C[C@H](C[C@H](C3)N)C(F)(F)F

InChI Key InChIKey=BJXYHBKEQFQVES-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50666916   

TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666916BDBM50666916(Enpatoran | M5049 | ENPATORAN | M-5049)
Affinity DataIC50: 74nMAssay Description:Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666916BDBM50666916(Enpatoran | M5049 | ENPATORAN | M-5049)
Affinity DataIC50: 285nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)