BDBM50030282 CHEBI:51052::Lucanthone

SMILES CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12

InChI Key InChIKey=FBQPGGIHOFZRGH-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50030282   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50030282(CHEBI:51052 | Lucanthone)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human APE1 after 25 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50030282(CHEBI:51052 | Lucanthone)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of full length human APE1 expressed in Escherichia coli BL21/DE3 assessed as inhibition of incision of depurinated supercoiled pUC18 plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50030282(CHEBI:51052 | Lucanthone)
Affinity DataKd:  89nMAssay Description:Binding affinity to full length human APE1 expressed in Escherichia coli BL21/DE3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50030282(CHEBI:51052 | Lucanthone)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of tau (unknown origin) aggregation expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50030282(CHEBI:51052 | Lucanthone)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of amyloid beta 40 peptide (unknown origin) aggregation incubated for 2 hr by ThT fluorescence based spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed