BDBM50560402 LIK-066::Licogliflozin::Lik066::USRE49080, Example 62

SMILES CCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI Key InChIKey=XFJAMQQAAMJFGB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50560402   

TargetSodium/glucose cotransporter 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50560402(Licogliflozin | Lik066 | LIK-066 | USRE49080, Exam...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50560402(Licogliflozin | Lik066 | LIK-066 | USRE49080, Exam...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50560402(Licogliflozin | Lik066 | LIK-066 | USRE49080, Exam...)
Affinity DataIC50: 0.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2022
Entry Details
US Patent

TargetSodium/glucose cotransporter 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50560402(Licogliflozin | Lik066 | LIK-066 | USRE49080, Exam...)
Affinity DataIC50: 22nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2022
Entry Details
US Patent