BDBM50017129 (S)-1-((S)-2-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)pyrrolidine-2-carboxylic acid::(S)-1-[(R)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid::(S)-1-{(S)-2-[1-((S)-Ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid::(S,S,S)-1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid::(SSS)1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid::1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid::1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid (Enalapril)::1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid(Enalapril)::2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid(enalapril)::CHEMBL578::ENALAPRIL::Enalapril maleate::Lexxel::Teczem::Vaseretic::Vasotec

SMILES CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

InChI Key InChIKey=GBXSMTUPTTWBMN-UHFFFAOYSA-N

Data  1 KI  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50017129   

TargetAngiotensin-converting enzyme(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetSolute carrier family 15 member 1(Human)
The University of Michigan

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 4.50E+6nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSolute carrier family 15 member 1(Human)
The University of Michigan

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.50E+7nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.20E+3nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme in Hog plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetSuccinyl-diaminopimelate desuccinylase(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Loyola University

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Haemophilus influenzae recombinant DapEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMultidrug and toxin extrusion protein 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetAngiotensin-converting enzyme(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 8.00E+3nMAssay Description:In vitro inhibitory activity against rabbit lung Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 1.27E+3nMAssay Description:Compound tested in vitro for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 140nMAssay Description:Compound was tested for its inhibitory potency against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of guinea pig angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 140nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 4.5nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 123nMAssay Description:Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2016
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 2nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 800nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme in rabbit lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetSolute carrier family 15 member 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataKi:  4.30E+6nMAssay Description:TP_TRANSPORTER: inhibition of D-Phe-L-Gln uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed