BDBM50136674 (3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine::(3R)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine::(R)-duloxetine::CHEMBL336920::LY248685::US20250042884, Compound R-duloxetine

SMILES CNCC[C@@H](Oc1cccc2ccccc12)c1cccs1

InChI Key InChIKey=ZEUITGRIYCTCEM-UHFFFAOYSA-N

Data  8 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50136674   

TargetSodium-dependent dopamine transporter(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataIC50: 809nMAssay Description:Inhibition of [3H]DA reuptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of [3H]5HT reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataIC50: 13.2nMAssay Description:Inhibition of [3H]NE reuptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataIC50: 660nMAssay Description:Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
Shanghai Leado Pharmatech Co.

US Patent
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataIC50: 35.5nMAssay Description:Ion Works Barracuda (IWB) automated patch clamp detection was used as test method: HEK293 cells stably expressing TRPA1 were placed in DMEM medium co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  8.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  15.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  61.3nMAssay Description:Displacement of [125I]RTI-55 from human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  550nMAssay Description:Displacement of [125I]RTI-55 from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50136674((R)-duloxetine | LY248685 | (3R)-N-methyl-3-(1-nap...)
Affinity DataKi:  659nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed