BDBM50088222 (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pentanedioic acid::CHEMBL301536::E-2-Amino-4-(3-naphthalen-2-yl-allyl)-pentanedioic acid(LY339434)::LY-339434

SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O

InChI Key InChIKey=KNAYYBRIBNEIAL-UHFFFAOYSA-N

Data  16 KI  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50088222   

TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50:  2.50E+3nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50: >3.00E+5nMAssay Description:Agonist activity at GluA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration against human GluR6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at GluK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at GluK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50:  800nMAssay Description:Compound was tested for agonistic activity on rat dorsal root ganglion neurons (thought to express GluR5 receptors)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50:  2.50E+3nMAssay Description:Effective concentration against GluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  14nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  15nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  15nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  617nMAssay Description:Ability to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  617nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 4 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 1 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]AMPA as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]AMPA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  1.37E+4nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]kainate as radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  1.54E+4nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]kainate as radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi:  1.54E+4nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed