BDBM50088197 CHEMBL58590::E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedioic acid(LY339295)::LY-339295

SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O

InChI Key InChIKey=NAVAGRCBXRSPTH-UHFFFAOYSA-N

Data  9 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50088197   

TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataEC50:  7.08E+4nMAssay Description:Effective concentration against human GluR6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataEC50:  2.80E+3nMAssay Description:Effective concentration required for evoking response in HEK293 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  8nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  423nMAssay Description:Ability to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  3.86E+3nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]AMPA as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi:  4.65E+3nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]AMPA as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 3 in HK293 cells using [3H]AMPA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi: >1.00E+4nMAssay Description:Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]AMPA as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed