BDBM50237607 Ansamycin::CHEBI:45367::LM-427::Mycobutin::Rifabutin

SMILES CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2C4=NC5(CCN(CC(C)C)CC5)NC4=C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(=O)c2c(O)c3C

InChI Key InChIKey=ATEBXHFBFRCZMA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50237607   

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50237607(CHEBI:45367 | Ansamycin | LM-427 | Mycobutin | Rif...)
Affinity DataIC50: 2.67E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50237607(CHEBI:45367 | Ansamycin | LM-427 | Mycobutin | Rif...)
Affinity DataIC50: 2.67E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50237607(CHEBI:45367 | Ansamycin | LM-427 | Mycobutin | Rif...)
Affinity DataIC50: 2.67E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50237607(CHEBI:45367 | Ansamycin | LM-427 | Mycobutin | Rif...)
Affinity DataIC50: 4.98E+4nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50237607(CHEBI:45367 | Ansamycin | LM-427 | Mycobutin | Rif...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50237607(CHEBI:45367 | Ansamycin | LM-427 | Mycobutin | Rif...)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nantes University

Curated by ChEMBL
LigandPNGBDBM50237607(CHEBI:45367 | Ansamycin | LM-427 | Mycobutin | Rif...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of biotinylated human PD-I /His-tagged PD-L1 (unknown origin) interaction incubated for 90 mins in dark condition by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed