BDBM420304 LLL-12

SMILES NS(=O)(=O)c1cccc2C(=O)c3c(O)cccc3C(=O)c12

InChI Key InChIKey=CQBHSRLUQDYPBU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 420304   

TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM420304(LLL-12)
Affinity DataIC50: 9.84E+3nMAssay Description:The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM420304(LLL-12)
Affinity DataIC50: 9.84E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
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In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM420304(LLL-12)
Affinity DataIC50: 98nMAssay Description:Inhibition of IL-6 induced STAT3 transcriptional activity in human HepG2 cells incubated for 1 hr followed by stimulation with IL-6 for 5.5 hrs by lu...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM420304(LLL-12)
Affinity DataIC50: 9.84E+3nMAssay Description:Inhibition of SARS-CoV-2 3CL protease expressed in Escherichia coli using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes of Health

LigandPNGBDBM420304(LLL-12)
Affinity DataIC50: 9.84E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21(DE3) using (KTSAVLQSGFRKME) as fluo...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed