BDBM50527040 LJN-452::LJN452::NVP-LJN452-NXA::Tropifexor

SMILES [H][C@]12CC[C@]([H])(C[C@@H](C1)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1)N2c1nc2c(F)cc(cc2s1)C(O)=O

InChI Key InChIKey=VYLOOGHLKSNNEK-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50527040   

TargetBile acid receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527040(LJN-452 | LJN452 | NVP-LJN452-NXA | Tropifexor)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at GST-tagged human FXR-LBD (193 to 472 residues) using biotinylated SRC-1 peptide as substrate incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527040(LJN-452 | LJN452 | NVP-LJN452-NXA | Tropifexor)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at FXR transfected in human HEK293T cells o-expressing pGL3/hBSEP/luc incubated for 24 hrs by Steady-Glo reagent based luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527040(LJN-452 | LJN452 | NVP-LJN452-NXA | Tropifexor)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed