BDBM50384788 LAPACHOL

SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]-1-[#6](=O)-[#6](=O)-c2ccccc2-[#6]-1=O

InChI Key InChIKey=MRLUTTBSEIAQHG-UHFFFAOYSA-N

Data  1 KI  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50384788   

TargetG-protein coupled receptor 35(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataEC50:  2.84E+3nMAssay Description:Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataEC50:  4.79E+4nMAssay Description:Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactama...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 4.66E+3nMAssay Description:Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 2(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 4.27E+4nMAssay Description:Inhibition of recombinant Cdc25B (unknown origin) using OMFP as substrate measured every 30 sec for 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 1(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 3.32E+4nMAssay Description:Inhibition of recombinant Cdc25A (unknown origin) using OMFP as substrate measured every 30 sec for 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Blood fluke)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 19nMAssay Description:Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 100nMAssay Description:Inhibition of human DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research Ahmedabad

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetLactoylglutathione lyase(Human)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)
Affinity DataKi:  3.72E+4nMAssay Description:Inhibition constant of compound against binding of Yeast Glyoxalase IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2019
Entry Details Article
PubMed