BDBM50029603 CHEMBL287919::L-745337::L745,337::N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-yl]-methanesulfonamide

SMILES CS(=O)(=O)Nc1cc2CCC(=O)c2cc1Sc1ccc(F)cc1F

InChI Key InChIKey=HDUWKQUHMUSICC-UHFFFAOYSA-N

Data  3 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50029603   

TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 activity in U937 microsomal assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 in human U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 23nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 2 expressed in human osteosarcoma 143 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 140nMAssay Description:Inhibition of purified recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of purified recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataKi:  1.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataKi:  8.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029603(N-[6-(2,4-Difluoro-phenylsulfanyl)-1-oxo-indan-5-y...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed